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In order to do this a drug has to be administered in some way. Unless the route of administration is directly into the blood stream, the drug has to be absorbed, usually by diffusion.
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The events that take place at a synapse, that is synthesis of neurotransmitter, storage in vesicles, release, interaction with receptors and eventual inactivation provide targets for drug action. Inactivation of a neurotransmitter can be by re-uptake into the neuron it was released from, or by the action of enzymes in the synaptic cleft.
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