Dilantin 250 mg
Ensure ECG, blood pressure and respiratory function are monitored throughout the duration of the infusion.
Administration should commence immediately after the mixture has been prepared and must be completed within 1 to 4 hours the infusion mixture should not be refrigerated. The diluted infusion mixture Phenytoin Sodium Injection plus normal saline should not be refrigerated. A faint yellow coloration may develop, however this has no effect on the potency of the solution. The IV maintenance dose should never be given qd in a single dose. Average time to steady state: 10 to 14days.
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Administration should commence immediately after the mixture has been prepared and must be completed within 1 to 4 hours the infusion mixture should not be refrigerated. Primary: Use undiluted drug and administer by slow intravenous injection at a rate not exceeding 50 mg per minute.
Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants. Clinicians are advised to initiate therapeutic drug monitoring in patients who require phenytoin since even small deviations from the recommended therapeutic range can lead to suboptimal treatment, or adverse effects. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Phenytoin is an anticonvulsant with a narrow therapeutic index. It is worth nothing that although phenytoin is highly protein bound, only the fraction unbound is able to exert a pharmacological effect. Phenytoin is often described as a non-specific dilantin 250 mg channel blocker and targets almost all voltage-gated sodium channel subtypes.
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Phenytoin works by slowing down impulses in the brain that cause seizures. Phenytoin is used to control seizures. It does not treat all types of seizures, and your doctor will determine if it is the right medicine for you. You should not use phenytoin if you also take delavirdine Rescriptor, dilantin 250 mg if you are allergic to ethotoin Peganone, fosphenytoin Cerebyx, or mephenytoin Mesantoin. Phenytoin may cause harm to an unborn baby, but having a seizure during pregnancy could harm both the mother and the baby.
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The originating document has been archived. In this leaflet: 1. What Phenytoin Injection is used for 2. Before you are given Phenytoin Injection 3. How Phenytoin Injection should be given 4. Possible side effects 5.
Phenytoin injection is contraindicated in patients with sinus bradycardia, sino-atrial block, second or third degree AV block, and Adams-Stokes syndrome because of the effects of the drug on ventricular automaticity. Intravenous phenytoin should not be used in patients with other cardiac conduction abnormalities e. Most cases of cardiac arrest occurred in patients with underlying cardiac disease. Severe cardiovascular reactions have occurred, including bradycardia, heart block, ventricular tachycardia, and ventricular fibrillation, which have resulted in asystole, cardiac arrest, and death in some cases. Although the risk of cardiovascular toxicity is increased with rapid intravenous administration, cardiac events have also been reported at or below the recommended infusion rates. Careful cardiac and respiratory monitoring is required during and after intravenous phenytoin administration.

The effectiveness of oral contraceptives can be reduced in this way. Certain drugs are excreted via expiration; the rate of excretion depends on plasma concentration, alveolar air concentration and blood-gas partition. Anaesthetic gases are the only group of drugs that are significantly excreted in expired air. A small amount of alcohol is excreted in this way but this accounts for only a small proportion of dilantin 250 mg overall elimination. Loss of drugs in sweat and breast milk occurs, but is of minor importance although the appearance of drugs in breast milk can have serious consequences for the nursing baby. Drugs can be administered to patients by a variety of routes and can be intended to have a local or systemic effect.
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