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Its flagship product contains aspirin and caffeine. Anacin was invented by William Milton Knight and was first to be used circa as stated in the patent. Anacin's mascot at the time was Ana Anacin, who was found in a number of ads for this product by Bayer. It was originally sold by the Anacin Co. American Home Products, now known as Wyeth, purchased the manufacturing rights in Their sponsorship spanned 18 of the program's 23 years on the air.

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Intra-arterial injections are rarely used. Radio-opaque substances and cytotoxic drugs are sometimes injected into arteries in the diagnosis and treatment of cancer. Intra-articular injections are sometimes used to administer a drug directly into a joint, for example with a corticosteroid in the treatment of arthritis or a contrast agent for imaging. Intraspinal and epidural injections are given under certain circumstances to have a local effect, either as anaesthesia or to treat infection of the central nervous system. For details of injection techniques, Whatever the route of administration, a drug must reach its site of action. In order to do this, the drug will have to cross several cell membranes to reach the blood (unless it is injected intravenously).

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Third generation β-blockers also cause peripheral vasodilation and do not adversely affect plasma lipid profiles. An example is celiprolol. Calcium channel blockers are used to treat ischaemic heart disease, arrhythmia and hypertension. This is a diverse group of drugs, which fall into three classes. They all block influx of calcium ions during depolarization of muscle cells. Class I calcium channel blockers work preferentially on calcium ion channels in cardiac muscle cells.


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