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Systemic piroxicam should be initiated only by specialists as a second-line treatment for arthritis, with patients who currently take piroxicam reassessed at a routine appointment. Revised warnings also highlight the need for caution when piroxicam is used with other drugs that may increase gastrointestinal risk eg, selective serotonin reuptake inhibitors class of antidepressants and low-dose aspirin. Patients should stop taking piroxicam and seek medical advice at the first occurrence of gastrointestinal symptoms. Patients who are receiving continuous long-term piroxicam treatment should be reassessed carefully in light of the increased risks of this treatment. If after full consideration of the risks and benefits there seems to be no alternative to piroxicam, specialist referral may be considered.

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This can happen through damage to DNA causing mutation of genes, activation of proto-oncogenes or damage to oncogene suppressors. Due to strict testing of new drugs during the developmental stages this should be a rare phenomenon. However, some drugs through immunosuppression, are known to increase the risk of tumour formation. For example, drugs used to treat cancers and drugs used to prevent transplant rejection are known to do this. It is important to realize that these are principles that have been derived from standard studies of drug action on average or normal individuals during the development process for new drugs.

Drugs of choice are imidazoles, terbinafine and amorolfine. Some of the preparations of these drugs are prescription-only medicines but they can be accessed and supplied by podiatrists. In severe extensive infection, oral terbinafine or griseofulvin may be needed. Even so, infection may take weeks or months to clear, particularly infection of the nails. Bacterial infection of the skin causes a condition known as cellulitis, which requires systemic antibiotics.
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Because podiatrists are likely to be treating fungal infections of the feet, some prescription-only antifungal drugs have been added to the list of exemptions for qualified podiatrists registered with the Health Professions Council. The first three of the following drugs are available in many preparations as over-thecounter medicines.
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Crisantaspase breaks down asparagine, which some tumour cells cannot synthesize. Normal cells can synthesize asparagine; therefore the drug is selective for certain tumours.
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