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Binding of neurotransmitter with its receptor is very brief, but it brings about stimulation or inhibition of the post-synaptic neuron. See Figure transmission. The events that take place at a synapse, that is synthesis of neurotransmitter, storage in vesicles, release, interaction with receptors and eventual inactivation provide targets for drug action. Inactivation of a neurotransmitter can be by re-uptake into the neuron it was released from, or by the action of enzymes in the synaptic cleft. NB While the exact involvement of a particular neurotransmitter in a particular CNS disorder is unknown, a question mark denotes more uncertainty about the neurotransmitter involvement. In the peripheral nervous system, transmission of information from neuron to neuron or effector is relatively simple but in the CNS, neurons are arranged into complicated systems and pathways.
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Authored by Eilene M Anderson, PA-C
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