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What is isosorbide dinitrate, and how does it work mechanism of action? Isosorbide dinitrate is converted in the body to isosorbide mononitrate which is the active chemical. Nitrates are vasodilators dilators of blood vessels.

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If bacteria are prevented from multiplying, they will eventually be destroyed by the normal immune reaction of the host. Infections in immunocompromized individuals (for example, those with human immunodeficiency virus infection and those on systemic corticosteroid, anticancer or immunosuppressant therapy) have to be treated with potent bactericidal drugs. The first drugs to be effectively used against bacterial infections were the sulphonamides introduced in the drugs have been necessary because of the problem of resistance. This is best exemplified by the staphylococcus strains now called MRSA (meticillin resistant Staphylococcus aureus, or multi-resistant Staphylococcus aureus. Meticillin is now unavailable in the United Kingdom).

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An overdose of isosorbide dinitrate can be fatal. The incidence of acute heart failure did not differ between the two groups 8 4.

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