Back to Medicines A to Z. Paroxetine is a type of antidepressant known as an SSRI selective serotonin reuptake inhibitor. It's often used to treat depression and also sometimes for obsessive compulsive disorder OCD, panic attacks, anxiety or post-traumatic stress disorder PTSD. Paroxetine helps many people recover from depression, and it has fewer unwanted effects than older antidepressants. If you have diabetes, paroxetine can make it more difficult to keep your blood sugar stable. Monitor your blood sugar more often for the first few weeks of treatment with paroxetine and adjust your diabetes treatment if necessary.

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Thank you for visiting nature. The aim of this study was to verify this phenomenon in diabetic rats and to elucidate the underlying mechanisms. Diabetes mellitus was induced in male SD rats by a high-fat diet combined with a low-dose streptozotocin injection. The pharmacokinetics of paroxetine and pravastatin were examined on d 1 and d Biochemical parameters including serum insulin, glucose and lipids were monitored during the treatments. An insulin-secreting cell line INS-1 was used for measuring insulin secretion. In diabetic rats, co-administration of paroxetine and pravastatin markedly increased the concentrations of both the drugs compared with administration of each drug alone. Furthermore, co-administration severely impaired glucose homeostasis in diabetic rats, as demonstrated by significantly increased serum glucose level, decreased serum and pancreatic insulin levels, and decreased pancreatic Insulin-2 mRNA and tryptophan hydroxylase-1 Tph -1 mRNA levels. The deregulation of glucose homeostasis by co-administration of paroxetine and pravastatin in diabetic rats can be attributed to enhanced paroxetine exposure.

Thomas I. Cremers, 0 5 mg paroxetine Dremencov, Fokko J. Bosker, Ben H. However, many depressed patients are also treated with benzodiazepines to alleviate increased anxiety and sleep disturbances normally associated with depression. This study aimed to assess, using in-vivo microdialysis, the effects of the benzodiazepines oxazepam or temazepan on the SSRI paroxetine-induced 5-HT increase in the hippocampus of freely moving guinea-pigs.

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Common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping, and sexual dysfunction. Paroxetine was approved for medical use in the United States in and initially sold by GlaxoSmithKline. Paroxetine is primarily used to treat major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, social anxiety disorder, panic disorder. It could be used also for agoraphobia, generalized anxiety disorder, premenstrual dysphoric disorder and menopausal hot flashes. A variety of meta analyses have been conducted to evaluate the efficacy of paroxetine in depression.

US Patent 4, describes certain compounds that possess anti-depressant activity. US Patent 5, describes paroxetine sulfonate salts, including paroxetine methane sulfonate also known as paroxetine mesylate. These sulfonate salts have advantageous properties in comparison to the prior known salts, including the hydrochloride salts. The paroxetine methane sulfonate or mesylate has also been approved for sale in many countries and is marketed as an immediate release tablet; e. Tabletted paroxetine compositions are of limited use in patients which have mental or physiological problems with swallowing tablets. The suspension must be well shaken before the use; failing to do so can result in an improper dose being administered.

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It works by increasing the amount of serotonin in the brain, a natural substance that helps maintain mental balance and elevate mood. This medication comes as a tablet, oral suspension, capsule, and as an extended-release tablet. It is usually taken once daily, with or without food. Common side effects of paroxetine include headache, fatigue, nausea, sleepiness, and weakness. Do not drive or operate heavy machinery until you know how paroxetine. Paroxetine is a prescription medicine used to treat depression.

Common Specialities. Health Query. I am consulting a psychiatrist for my anxiety problem from last 1 month. If yes how many days will it last? Psychologist, Delhi. Never self prescribe!

White coloured film-coated capsule shaped, biconvex tablets debossed with '56' on one side and 'C' with a deep break line on the other side. A low initial starting dose is recommended to minimise the potential worsening of panic symptomatology, which is generally recognized to occur early in the treatment of this disorder. Abrupt discontinuation should be avoided see section 4. Paroxetine should not be used in the treatment of children and adolescents under the age of 18 years. If, based on clinical need, a decision to treat is nevertheless taken; the patient should be carefully monitored for the appearance of suicidal symptoms.

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