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They are toxic drugs capable of causing skin reactions ranging from erythema to exfoliating dermatitis, inflammation of mucous membranes and blood dyscrasias. Penicillamine may inhibit production of inflammatory mediators and can delay the progress of disease.
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- Examples of bile acid sequestrants are colestipol and cholestyramine.
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These drugs are used to treat leukaemia, lymphoma, testicular cancer and lung cancer. Adverse reactions of vinca alkaloids are relatively mild. Some are due to the inhibition of other functions of microtubules.
Some of the preparations of these drugs are prescription-only medicines but they can be accessed and supplied by podiatrists. In severe extensive infection, oral terbinafine or griseofulvin may be needed. Even so, infection may take weeks or months to clear, particularly infection of the nails. Bacterial infection of the skin causes a condition known as cellulitis, which requires systemic antibiotics.

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This led to the withdrawal of rofecoxib in October for patients at high risk of developing gastrointestinal side effects.
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