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Androgens, the family of male sex hormones that includes testosterone, function as a fuel for growth — a quality that explains their central role in both normal development and prostate cancer.

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Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a composition of the R -bicalutamide and S -bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Bicalutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Bicalutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors but not for progestogen, estrogen, or glucocorticoid receptors. Consequently, Bicalutamide blocks the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue.

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Bicalutamide has a molecular weight of The inactive ingredients of CASODEX Tablets are lactose, magnesium stearate, methylhydroxypropylcellulose, polyethylene glycol, polyvidone, sodium starch glycollate, and titanium dioxide. See Drug-Drug Interactions below. CASODEX has no indication for women, and should not be used in this population, particularly for non-serious or non-life threatening conditions. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. These pharmacological effects have been observed with other antiandrogens.

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In combination with luteinizing hormone-releasing hormone LHRH analogue in stage D 2 metastatic prostate carcinoma. Take at the same time each day. Start treatment at same time as starting LHRH analogue. Moderate to severe hepatic impairment. Males with female partners of reproductive potential should use effective contraception during therapy and for days after final dose. Nursing mothers.

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Androgens stimulate prostate cancer cells to grow. The main androgens in the body are testosterone and dihydrotestosterone DHT. Most androgen is made by the testicles, but the adrenal glands glands that sit above your kidneys as well as the prostate cancer itself, can also make a fair amount. Lowering androgen levels or stopping them from getting into prostate cancer cells often makes prostate cancers shrink or grow more slowly for a time. In this operation, the surgeon removes the testicles, where most of the androgens testosterone and DHT are made.

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There are treatment orders casodex drug to address the condition. Casodex is a hormone-based chemotherapy. Bicalutamide competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens. It works by blocking the normal effect of the male hormone androgen. But hormone therapy alone does not cure prostate cancer. The U.

Bicalutamide comes as a tablet to take by mouth. It is usually taken with or without food once a day, either in the morning or evening. Take bicalutamide at around the same time every order casodex drug. You should begin taking bicalutamide on the same day you begin injecting the luteinizing hormone-releasing hormone. Take bicalutamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

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For which conditions is this drug approved? What is the mechanism of action? Casodex belongs to a group of drugs referred to as anti-androgens. Prostate cancer is stimulated to grow by the male hormone, testosterone. Anti-androgens inhibit the effects of testosterone on cancer cells, removing the growth stimulus.


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