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This prevents the formation of certain prostaglandins that would otherwise cause inflammation and pain. Other drugs act as false substrates for the enzyme so that an abnormal product is made instead of the normal one. The abnormal product then brings about the action of the original drug. Methyldopa can be used again as an example here. It is a false substrate for the enzyme that normally converts dopa into dopamine.
You should be able to answer the following questions using the material in this chapter. This chapter describes some disorders of the central nervous system and the drugs used to treat these conditions. It is an overview of a few disorders of the CNS, rather than an attempt to cover them all comprehensively.
Lipids do not dissolve easily in water. Therefore, they have to be transported in blood as lipoproteins. Lipoproteins are formed from a protein envelope, made of apoprotein, containing a variable mix of triglycerides and cholesterol.

Reactive depression is usually associated with stressful life events, whereas endogenous depression is a persistent alteration of mood with no obvious cause. However, this classification has largely been abandoned because there is often overlap between the two. For example mild so-called reactive depression can occur without an order avapro change in circumstances.
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Conversely, for a local effect, addition of a vasoconstrictor to the injection decreases the rate of removal of the drug from the site of injection. Depot preparations are designed to give a slow sustained release of drug. Drugs injected intravenously go directly into the blood stream and are rapidly distributed around the body. An advantage of intravenous injection is that it is possible to get high concentrations of a drug very quickly to its site of action, although this may also lead to toxic effects in other tissues. Disadvantages of intravenous injection are that it requires trained personnel using sterile techniques and once the drug has been given, mistakes cannot be rectified.
Three other types of cell are found in the epidermis. Merkel cells and melanocytes are found in the stratum basale. Merkel cells are attached to a sensory neuron and function to detect the sensation of touch. Melanocytes produce the pigment melanin, which contributes to skin colour and provides some protection against sunlight. Langerhans cells are found in the stratum spinosum.
The first effects are tremor and restlessness because inhibitory pathways are affected first. As the dose increases, convulsions may occur. Initially, due to central nervous system effects, the rate of respiration increases. As the drug concentration increases, depression of the medulla results in breathing becoming rapid and shallow. Larger doses depress respiration and lower the level of consciousness of the patient.
Insomnia can be secondary to other conditions, for example anxiety or depression. Other causes are factors such as stress and excessive noise, jet lag, shift work, physical illness and pain, stimulants, sleep apnoea or poor habits at bedtime. Primary insomnia is insomnia of no obvious cause. An anxiolytic is a drug that reduces feelings of anxiety, whereas a hypnotic is a drug that induces sleep. The two terms are interchangeable in the sense that most anxiolytics will induce sleep when given at night and most hypnotics will cause sedation when given during the day.
This highly toxic drug is reserved for psoriasis that is cheap gasex to other systemic treatment and it should only be used under supervision of a dermatologist. Efalizumab is a monoclonal antibody that inhibits the activation of T lymphocytes. It is licensed for severe plaque psoriasis resistant to other systemic treatment and phototherapy. Presumably, efalizumab works by inhibiting the inflammatory component of this type of psoriasis. Retinoids are synthetic vitamin A derivatives.
Authored by Dr. Gordon Phillip Smith, DDS
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Cimetidine, a drug used to treat stomach ulcers, can inhibit the metabolism of several potentially toxic drugs such as phenytoin and theophylline. Erythromycin, an antibiotic, similarly increases the activity of theophylline, warfarin and digoxin.
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