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It is also formulated in combination with a sulphonamide, when it is known as co-trimoxazole, to treat pneumonia in patients with HIV. Due to the synergistic effect of the two drugs, this combination is more effective than either drug alone. Adverse effects on the production of blood cells occur with prolonged use of trimethoprim. The quinolones inhibit a bacterial enzyme, DNA gyrase. This enzyme is involved in the unwinding of DNA prior to replication. Inhibition of this enzyme prevents DNA replication and bacterial cells cannot survive.
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Neurofibrillary tangles are found in neurons and may be collections of abnormal microtubule proteins, which form as a result of cell destruction.
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Those that do can be treated with primaquine, which prevents the disease from recurring. Primaquine is usually taken in combination with chloroquine.
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