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Large inter-individual variation in the response to desmopressin is observed. We aim to describe the response to desmopressin in moderate hemophilia A patients and to identify predictors.
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Manipulation of pH to increase the rate of cheap price on desmopressin of a drug has a practical use in cases of overdose as shown by the following examples. Administration of sodium bicarbonate increases the alkalinity of the tubular filtrate therefore acidic drugs, for example aspirin and barbiturates become ionized and cannot diffuse back from the tubules to the plasma. Hence their rate of elimination is increased. This may be useful in the event of an overdose. Conversely, the elimination of basic drugs such as amfetamine, antihistamines, morphine and tricyclic antidepressants can be increased by making tubular filtrate more acidic by administration of ammonium chloride.
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Another adverse effect of cancer chemotherapy is known as tumour lysis syndrome.
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