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- The contraction phase is known as systole and the relaxation phase of the heart is known as diastole.
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A well-documented historical example of this is the competition between penicillin and probenecid. Penicillin is a drug that is approximately eliminated by a kidney transport system. This was a disadvantage in the days when penicillin was expensive and difficult to produce, because its action was prematurely terminated unless high doses were given. Penicillin used to be administered together with probenecid. Probenecid is slowly transported by the same system and therefore considerably reduces the elimination of penicillin.
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However, she tells you she is really worried about the operation because she had a bad experience with an operation when she was a child.
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