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Because compensation occurs, there must be takes the form of increased activity in the remaining dopaminergic neurones and increase in numbers of receptors. Dopamine pathways normally balance cholinergic pathways in the basal nuclei and many of the symptoms of Parkinsons disease are thought to be due to over activity of cholinergic pathways. Therapy therefore aims to improve dopaminergic transmission or inhibit cholinergic pathways to restore the balance. Idiopathic Parkinsons disease occurs due to degeneration of dopamine neurons with no obvious cause. There may be a genetic susceptibility, but no causal gene has been found, although mutation of the so-called Parkin gene is associated with early-onset Parkinsonism. Post-encephalitic Parkinsonism followed an epidemic of viral encephalitis between Drug-induced Parkinsonism can occur as an adverse effect to drugs used to treat psychotic disorders.

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These drugs also reduce muscle tone, which is useful during surgery. They have no analgesic effect, so may be used together with opioid analgesics.

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With the administrator or with the postman (who unknowingly pushes the medicine through the letter box). Whichever professional is considered, it should be noted that neither of these groups can legally work within a PGD. Also, any regulations and related guidance must be complied with strictly. Another example noted in some PGDs is that working practices may not be in line with Summary of Product Characteristics for that medicinal product. For example some PGDs have indicated that the amount of Omnipaque (an X-ray contrast agent) to be administered can exceed that outlined on the product information sheet.


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The pharmacology content of the training courses will include general principles of pharmacology: absorption, distribution, metabolism and excretion; individual variation to drug therapy, adverse drug reactions, drugdrug interactions, interactions with other diseases and drug interaction with receptors and the legal basis for prescribing, supply and administration of medicines, including regulatory aspects of controlled drugs.

09.06.2019
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