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They have no sedative action or analgesic effects. Examples of non-depolarizing neuromuscular blockers are pancuronium and atracurium.
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Granisetron is a serotonin antagonist. Serotonin receptors are also found in the chemotrigger zone of the medulla and in the gastrointestinal tract. Stimulation of them plays a role in emesis. Both domperidone and granisetron are used to counteract emetic effects of therapeutic radiography. Loperamide is an opiate drug that decreases motility of the intestine. It does not cross the bloodbrain barrier easily and therefore does not have the central nervous system effects of other opiates.
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Their use cannot be justified for trivial illnesses but they may be used for life-threatening conditions when the benefits outweigh the risks. Drugs with a TR of one or less cannot be used therapeutically.
02.06.2017
Leon
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Thiopental is an anaesthetic but has no analgesic action; indeed, it may increase perception of pain.
03.06.2018
Karl
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Its mode of action is to inhibit neuromuscular transmission in the worm. It does this by acting on GABA receptors, which causes the opening of chloride channels and hyperpolarization of muscle cells in the worm.
19.05.2016
Friedrich
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Loop diuretics inhibit sodium and chloride ion transport in the ascending limb of the loop of Henl´e and therefore prevent water reabsorption there. An example of a loop diuretic is furosemide.
06.05.2019
Ernst
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