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Risperidone is a benzisoxazole derivative approved by the FDA for treatment of schizophrenia in, for short-term treatment of the mixed and manic states of bipolar disorder in, and for treatment of irritability in children with autism in From: Pharmacology and Physiology for Anesthesia, David Germann CYP3A4 also appears to be involved, to a lesser extent, in metabolism of risperidone and 9-hydroxy-risperidone. The minor metabolic routes for risperidone include oxidative N-dealkylation and hydroxylation to 7-hydroxy-risperidone Fig. These metabolites do not exhibit pharmacologic effects. Breck Borcherding John T. Risperidone is labeled for use in the treatment of schizophrenia and the manic phase of bipolar disorder, either alone or in conjunction with lithium or valproate in adults.
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