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Selegiline is a methamphetamine derivative and a potent, irreversible, monoamine oxidase B—selective inhibitor primarily used for the treatment of Parkinson's disease. Selegiline is a methamphetamine derivative and a potent, irreversible, MAO-B-selective inhibitor primarily used for the treatment of Parkinson's disease. Ten milligrams of selegiline daily has no effect on the symptoms of narcolepsy, but 20 to 30 mg improves alertness and mood and reduces cataplexy, an effect comparable to d -amphetamine at the same dose. The fact that this compound is often considered as a simple MAO-B inhibitor rather than an amphetamine precursor deserves special mention. Carl P. Log on to ExpertConsult. Contraindications —hypersensitivity to drug or class, opiate use. Selegiline should be used during pregnancy and lactation only if the benefit justifies the potential perinatal risk.
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Murphy, Chuang C. DOI : Selegiline is a selective, non-competitive, irreversible inhibitor of monoamine oxidase MAO B, and is widely used as an adjunct to Ldopa in the treatment of Parkinsons disease. Recent interest in selegiline has focused on its complex neuroprotective actions against a variety of neurotoxins, and on the pathological buys selegiline of oxidative stress and apoptosis which cause neuronal death in chronic neurodegenerative brain disorders, such as Parkinsons disease, Alzheimers disease, and amyotrophic lateral sclerosis. Recent molecular biological evidence suggests that selegiline may also alter the expression of glyceraldehydephosphate dehydrogenase GAPDH and other redox active molecules such as thioredoxin in brain neurons. Ruey-Meei Wu, Dennis L.

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Deprenyl is metabolized by the liver through cytochrome P and excreted via the urine. It has a hour half-life when taken orally.
- Selegiline is used to treat canine cognitive dysfunction and a type of Cushing's disease caused by a pituitary tumor.
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Auto-Ship eligible. Selegiline Capsules for Dogs may be used for the control of clinical signs associated with canine cognitive dysfunction syndrome CDS and uncomplicated canine pituitary dependent hyperadrenocorticism PDH.
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Low levels of this chemical are associated lanoxin 0 125mg Parkinson's disease. Serious drug interactions can occur when certain medicines are used together with selegiline. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using. You should not use selegiline if you are allergic to it, or if you have taken fluoxetine Prozac, Sarafem and others within the past 5 weeks. Some medicines can cause unwanted or dangerous effects when used with selegiline.
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