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I live in the Canton of Petrea Thule, which is found in the great Barony of Septentria, largest and most populace barony of the Kingdom of Ealdormere. Or you may know this place as Peterborough, Ontario, Canada. My start in the SCA was in October Shortly after moving here to Peterborough. I came here for the university, I stayed for the SCA.
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Adverse effects of phenobarbital include sedation, which can occur at therapeutic doses and is a serious disadvantage in a drug that would have to be taken for many years. Other adverse effects include megaloblastic anaemia, mild hypersensitivity reactions and osteomalacia. Phenobarbital is dangerous in overdose, producing coma and respiratory and circulatory failure and consequently is not much used nowadays. Most benzodiazepines are not useful in treating epilepsy because of their sedative effects and exacerbation of seizures on withdrawal. However, intravenous diazepam is used to treat status epilepticus.
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There may be a genetic susceptibility, but no causal gene has been found, although mutation of the so-called Parkin gene is associated with early-onset Parkinsonism. Post-encephalitic Parkinsonism followed an epidemic of viral encephalitis between Drug-induced Parkinsonism can occur as an adverse effect to drugs used to treat psychotic disorders.
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