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- There is elevation of acute phase plasma proteins, which are released during inflammation and often vasculitis and damage to heart muscle.
- The most useful drugs are central acetylcholinesterase inhibitors, for example donepezil.
- There is also elevation of mood, although this may be due to alleviation of distressing symptoms.
- Normal cells can synthesize asparagine; therefore the drug is selective for certain tumours.
- Initially, episodes of inflammation last only a week or so with no symptoms in between.
Adverse reactions include the risk of acute renal failure due to blockage of tubules because contrast agents are relatively insoluble. Adequate water intake by the patient is essential to reduce the risk of renal toxicity.
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Alteration in absorption can also make older people more vulnerable to the ulcerogenic effects of some drugs, for example non-steroidal anti-inflammatory drugs. Distribution of drugs around the body is likely to be different in older people because of changes in body composition, plasma protein concentration and blood flow to major organs.
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The use of broad-spectrum antibiotics can reduce populations of normal flora (the resident harmless bacteria that we all have), which can cause adverse effects and superinfections of fungi and other drug-resistant micro-organisms. Bacteriostatic antibiotics inhibit bacterial growth and proliferation, while bactericidal antibiotics actually kill bacteria. Many antibiotics are bacteriostatic at low concentrations and bactericidal at higher concentrations. This distinction is often not important clinically. If bacteria are prevented from multiplying, they will eventually be destroyed by the ativan without a prescription immune reaction of the host. Infections in immunocompromized individuals (for example, those with human immunodeficiency virus infection and those on systemic corticosteroid, anticancer or immunosuppressant therapy) have to be treated with potent bactericidal drugs.
It may also be of more general use to any health care professional involved in patient care, especially those who administer medicines under patient group directions. The book is arranged into three parts. In the first part, Principles of Pharmacology, two chapters cover administration, absorption, distribution, metabolism and excretion of drugs and adverse drug reactions, drugdrug interactions, individual response to drugs and targets for drug action. The second part is Systemic Pharmacology, which covers common disorders of the major body systems and their treatment. The cardiovascular, respiratory, endocrine, musculoskeletal, skin and central nervous systems are considered. An outline of normal physiology of the systems is included where appropriate and relevant diseases described briefly.
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Mercaptopurine is a purine analogue that substitutes for purine bases in the synthesis of DNA.