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These drugs inhibit the re-uptake of noradrenaline and dopamine. Increase in levels of these two transmitters in the prefrontal cortex is thought to increase inhibitory control in the limbic system. Side effects of psychostimulant drugs include insomnia, restlessness, irritability, nervousness, dizziness, tremor and sometimes psychosis. Dr James Parkinson first described this disease in palsy. Parkinsons disease is the second most common neurodegenerative disease after Alzheimers disease, affecting The disease is progressive and usually begins with a fine tremor of the extremities.

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Modern diagnostic classifications depend on the presence or absence of positive or negative symptoms as well as the duration of symptoms according to either the ICD- Negative symptoms are social withdrawal, buy metformin india of emotional responsiveness and apathy; positive symptoms are hallucinations, thought disturbances, delusions, restlessness and aggression. Some psychoses can be secondary to other diseases such as infection and peripheral vascular disease or intoxication with drugs or alcohol, but most often the aetiology is unknown. Schizophrenia appears to have a genetic basis.

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They are of no use in IDDM, but do buy metformin india a place in the treatment of NIDDM. There are two main groups of oral hypoglycaemics: the sulfonylureas and the biguanides. There are some newer drugs recently added or in development.

The second case study is a patient who could be seen by any health care professional. The use of drugs to eradicate micro-organisms and parasitic worms in the body is called chemotherapy. Drugs that are used to treat infections with micro-organisms are known as antimicrobial drugs or antibiotics. The first antibiotics were naturally produced by micro-organisms; nowadays many are produced synthetically.

However, as one of the main functions of the liver is the metabolism of toxic substances produced during normal metabolic processes, it is not surprising that the majority of drug metabolism takes place in the liver. Some drugs are almost completely inactivated by first pass metabolism in the liver. The extent of first pass metabolism varies from individual to individual and can lead to unpredictable effects for some drugs administered orally.

What advice can you give Mrs Dexter about what appears to be neuropathic pain. You may need to refer to Chapter treatment of neuropathic pain in the BNF. After cardiovascular disease, cancer is the second major cause of death in the developed world, being the cause of about one in five deaths. It is increasingly common over the age of those commonly occurring such as lung cancer, breast cancer and colon cancer as well as much rarer conditions, some of which occur almost exclusively in children (for example retinoblastoma). Cancer is therefore not one disease but many, which may all be different and require different approaches to therapy.

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These anti-cancer drugs do not fit into the other groups. Most are cytotoxic in some way and cause the usual side effects.

  • Thymectomy increases the chances of a patient going into remission, although it may take for the benefits to be seen.
  • He was discharged with a prescription for warfarin and told to go to the anticoagulant clinic on a weekly basis.
  • Eyes should be examined for signs of retinal disease annually so that treatment can begin before damage to vision occurs.
  • The aim of chemotherapy is either, to affect a cure by reducing the size of a tumour so that it can be surgically removed or it disappears altogether, or to prolong life and provide palliative care.
  • Not surprisingly, they have a similar effect to ACE inhibitors but this is brought about by preventing angiotensin II from binding to its receptors.
  • Do you think this patient would be suitable for supplementary prescribing with a clinical management plan and why.
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The parathyroids are small, but important, glands involved in regulation of blood calcium levels together with calcitonin secreted by the thyroid gland and vitamin D. Calcitonin has a use in treating Pagets disease and osteoporosis.

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Early signs of lithium toxicity are vomiting and severe diarrhoea followed by tremor, ataxia, renal impairment and convulsions. Many non-steroidal anti-inflammatory drugs interact with lithium to increase its plasma concentration and risk of toxicity.

Authored by Katherine Robinson, PA


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ACE inhibitors are used to treat cardiac failure and hypertension. Inhibition of ACE prevents formation of angiotensin II, which is a powerful vasoconstrictor (see Figure resistance and therefore reduction in blood pressure.

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Psychoses are a group of disorders in which patients have a distorted perception of reality and they include reactive psychosis, paranoiddelusional psychosis, some types of mania and schizophrenia.

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