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With ageing, body composition changes such that there is more body fat with respect to total body weight, and the proportion of body water falls. The importance of this is that highly lipid-soluble drugs, for example benzodiazepines, tend to have prolonged duration of action. Plasma protein concentration also falls with age. This means that for extensively protein bound drugs there will be a greater concentration of free drug than expected.
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One percent hydrocortisone cream or ointment, which is available as a pharmacy medicine is usually effective.
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30.08.2016
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Initial referral from GPs of these high-risk patients includes the drawing up of pre-arranged CMPs, with the patients consent, before consultation with the podiatrist.
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Drugs with a TR of one or less cannot be used therapeutically.
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