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The anaesthetic is injected in or around the area requiring anaesthesia. The drug diffuses through the tissues and directly affects the nerve endings in the skin preventing conduction of nerve impulses.

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All these drugs either improve the blood supply to the myocardium or reduce its metabolic demand for oxygen, or both. Beta blockers are also useful in treating hypertensive patients who do not respond adequately to other antihypertensive drugs, and some types of arrhythmia because they slow the heart rate.

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