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What is clonazepam, and how does it work mechanism of action?
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Clonazepam, sold under the brand Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and the movement disorder known as akathisia. Common side effects include sleepiness, poor coordination, and agitation. Clonazepam was patented in and went on sale in in the United States from Roche. Clonazepam is prescribed for short term management of epilepsy and panic disorder with or without agoraphobia. Clonazepam, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects. Clonazepam has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be achieved at low plasma levels of clonazepam.
In general, benzodiazepines are used as a sedative or to decrease seizures or anxiety. Nonmedicinal ingredients: croscarmellose sodium, lactose, magnesium stearate, microcrystalline cellulose, and polyethylene glycol. Toenail Fungus: Treatment Options Table. More on CHealth.
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Discontinuation of treatment: Withdraw treatment gradually; decrease the dose q3Days by 0. Concomitant use of benzodiazepines and opioids may result in profound respiratory depression, coma, and death; administer concomitantly when there are no alternative options; limit dosages and durations to minimum required; monitor for signs and symptoms of respiratory depression and sedation. Not recommended in patients with depressed neuroses, psychotic reactions, severe respiratory depression, myasthenia gravis allowable in limited circumstances, acute alcohol intoxication. Use with caution in patients with a history of drug abuse or acute alcoholism; drug dependency possible; prolonged use may result in psychological and physical dependence. When used in patients in whom several different types of seizure disorders coexist, clonazepam may increase incidence or precipitate onset of generalized tonic-clonic seizures grand mal ; may require addition of appropriate anticonvulsants or increase in dosages; concomitant use of valproic acid and clonazepam may produce absence status.
In general, benzodiazepines are used as a sedative or to decrease seizures or anxiety. Clonazepam is used to treat seizure disorders. It helps by slowing the activity of the nerves in the brain i. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor. Do not give this medication to anyone else, even if they have the same symptoms as you do.
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Klonopin may be used alone or with other medications. These are not all the possible side effects of Klonopin. Klonopin, a benzodiazepine, is available as scored tablets with a K-shaped perforation containing 0. It is a light yellow crystalline powder. It has a molecular weight of
Clonazepam may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. Your doctor may need to change the dosages of your medications and will monitor you carefully. Drinking alcohol or using street drugs during your treatment with clonazepam also increases the risk that you will experience these serious, life-threatening side effects. Do not drink alcohol or use street drugs during your treatment. Clonazepam is used alone or in combination with other medications to control certain types of seizures. It is also used to relieve panic attacks sudden, unexpected attacks of extreme fear and worry about these attacks.
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Other more specialized treatments are cryotherapy, using liquid nitrogen, electrosurgery, surgical excision, bleomycin injections and carbon dioxide laser. Fungal infection of the skin and nails will be familiar to podiatrists. There are many topical antifungal drugs available over the counter and of varying efficacy. Drugs of choice are imidazoles, terbinafine and amorolfine. Some of the preparations of these drugs are prescription-only medicines but they can be accessed and supplied by podiatrists.
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Antihistamines and corticosteroids, if needed for adverse reactions, should never be mixed in the same syringe because precipitation would occur. Contrast agents are among the safest medicinal products in use.
- Stimulant laxatives work by stimulating enteric nerves, which results in smooth muscle contraction and an increase in peristalsis.
- You should be able to answer the following questions using the material in this chapter.
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- They are generally most appropriate to manage a single treatment episode or series of episodes of the same condition.
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Some drugs need conversion by an enzyme from an inactive pro-drug into an active form before they can be of therapeutic use. Methyldopa, above, could be said to be a prodrug and methylnoradrenaline the active drug.
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Thromboxanes promote platelet aggregation. There are many different drugs of this type, none of which is a more potent analgesic than aspirin.
Topical anaesthesia prior to venepuncture may be necessary. This technique with EMLA cream may be used by clonazepam 2mg pills under patient group directions. Laxatives and evacuants are used to empty the bowel prior to the administration of barium contrast agents and abdominal radiological examination. There are four types of laxatives depending how they work: bulk-forming laxatives; softenerslubricants; osmotic laxative; and stimulant laxatives. Bulk-forming laxatives work by increasing the volume of non-absorbable solid residue in the bowel. They act by absorbing water, swelling and stimulating peristalsis.
They are analogues or antagonists of normal cell constituents. Mercaptopurine is a purine analogue that substitutes for purine bases in the clonazepam 2mg pill of DNA. It is converted to a false nucleotide that inhibits the formation of normal DNA. Adverse effects of mercaptopurine are similar to methotrexate. Mercaptopurine is metabolized by xanthine oxidase. It should be used with caution in combination with allopurinol because allopurinol inhibits xanthine oxidase.
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