Discontinuation of treatment: Withdraw treatment gradually; decrease the dose q3Days by 0. Concomitant use of benzodiazepines and opioids may result in profound respiratory depression, coma, and death; administer concomitantly when there are no alternative options; limit dosages and durations to minimum required; monitor for signs and symptoms of respiratory depression and sedation. Not recommended in patients with depressed neuroses, psychotic reactions, severe respiratory depression, myasthenia gravis allowable in limited circumstances, acute alcohol intoxication. Use with caution in patients with a history of drug abuse or acute alcoholism; drug dependency possible; prolonged use may result in psychological and physical dependence. When used in patients in whom several different types of seizure disorders coexist, clonazepam may increase incidence or precipitate onset of generalized tonic-clonic seizures grand mal ; may require addition of appropriate anticonvulsants or increase in dosages; concomitant use of valproic acid and clonazepam may produce absence status.

Clonazepam is a benzodiazepine; consequently, tolerance may potentially develop over time, causing a diminishment of efficacy. Clonazepam is used alone or with other seizure medicines to treat absence and myoclonic seizures especially in Lennox Gastaut syndrome, and can help stop seizure clusters. An example of a cluster might involve a person who has one complex partial seizure in the morning and three or four more seizures over the course of the day, just once a month. For seizures that mainly occur during sleep or shortly after awakening, giving clonazepam or another benzodiazepine at bedtime can be very effective in controlling the seizures and improving sleep. Clonazepam can be taken either with or without food. It is recommended that if the doses are not equally divided during the day, the largest dose should be taken at bedtime to minimize the possibility of daytime sedation. For example, if you've been prescribing 0.

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Suicidal thoughts or behavior monitor. Adult: Initially up to 0.

Do not start, stop, or change the dose of any drug without checking with your doctor. Benzodiazepine anticonvulsants Benzodiazepines.

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A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop Label 11, 12, 13, The agent has also been indicated clonazepam 0.5mg odt treating panic disorder Label 7, 11, 12, 13, The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses Label 7, 8, 11, 12, 13, Since being first patented in and then released for sale from Roche in the US in 9, 10, clonazepam has experienced a storied history in the treatment of the aforementioned medical conditions. Unfortunately, however, like most benzodiazepines, clonazepam use has also been associated with recreational use and drug abuse Label 11, 12, 13,

Clonazepam, sold under the brand Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and the movement disorder known as akathisia. Common side effects include sleepiness, poor coordination, and agitation. Clonazepam was patented in and went on sale in in the United States from Roche. Clonazepam is prescribed for short term management of epilepsy and panic disorder with or without agoraphobia. Clonazepam, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects.

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It is a light yellow crystalline powder. It has a molecular weight of Clonazepam is rapidly and completely absorbed after oral administration. Maximum plasma concentrations of clonazepam are reached within 1 to 4 hours after oral administration. This derivative can be acetylated, hydroxylated and glucuronidated. Clonazepam pharmacokinetics are dose-independent throughout the dosing range.

Do not start, stop, or clonazepam 0.5mg odt the dose of any drug without checking with your doctor. All drugs may cause side effects. However, many people have no side effects or only have minor side effects. These are not all of the side effects that may occur. Clonazepam side effects in more detail.

As with other benzodiazepines, clonazepam should be used with extreme caution in patients with pulmonary disease or conditions associated with compromised respiratory function such as sleep apnea, bronchitis, pneumonia, asthma, or chronic obstructive pulmonary disease COPD. Additionally, avoid coadministration with other CNS depressants, especially opioids, unless no other alternatives are available as coadministration significantly increases the risk for respiratory depression, low blood pressure, and death. Clonazepam should not be used in patients with preexisting respiratory depression, cases of shock, or coma because the drug can worsen respiratory and CNS depression. In patients who snore regularly, partial airway obstruction may convert to obstructive sleep apnea with benzodiazepine administration. Clonazepam may produce hypersalivation and may aggravate conditions in which patients have difficulty handling secretions.

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