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Cystic fibrosis is a serious inherited disorder where abnormally viscous mucus can cause obstruction of bronchioles and lead to frequent infection. Management of cystic fibrosis is through a combination of physiotherapy and antibiotics.
- Collectively cardiac muscle is known as the myocardium.
- Diagnostic efficacy, including diuretics, cardiac stimulation agents and smooth muscle relaxants.
- Symptoms are high metabolic rate, increased temperature and sweating, nervousness, tremor, tachycardia, increased appetite and loss of weight, goitre and protrusion of the eyeballs (exophthalmia).
- This results in irreversible inhibition of viral polymerase.
- Oral corticosteroids are sometimes needed in short courses to manage acute exacerbation and longer term when other drugs do not prevent severe attacks of asthma.
- Adverse reactions to iodine contrast agents are rare, especially with the newer non-ionic dimers of low osmolality.
In some patients, something that cannot be predicted is that a drug or drug metabolite can combine with tissue proteins to form an antigenic conjugate. In this situation, the patient shows a response, which can be described under one of the classical definitions of allergic response (that is, type see below).
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Apoptosis is genetically programmed cell destruction that removes old, redundant and abnormal cells. This guards against mutations surviving and cells becoming malignant.
Drug development involves investigation of drug action in order to determine suitable and effective dosage regimes, to allow likely adverse effects to be determined and to ensure safety in use as far as possible. Clinical trials are usually done on young, healthy male volunteers. Obviously, in therapeutic use drugs are taken by many different sectors of the general population least likely to be young, healthy men. Drug trials therefore continue after a drug is on the market through monitoring by the MHRA of the first patients using new drugs and through the yellow card scheme of reporting adverse reactions thereafter. It is possible to predict, and to some extent avoid, likely adverse effects in particular populations using knowledge of factors that affect the four processes above in different patient groups.
Although drugs do appear in faeces, expired air, sweat and breast milk, these are normally minor routes of excretion. The following two case studies could be of relevance to any health care professional. Mr Robinson is a every from which he seems to be recovering well. He tells you that his doctor at the hospital has put him on a new drug to thin his blood and told him that he must not drink alcohol. What can you tell Mr Robinson about the drug he is taking and how can you explain to him the importance of not drinking with this medication.
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Ionization can adversely affect the heart and central nervous system and may cause allergic reactions.
However, since the duration of action of insulin preparations varies from patient to patient, combinations of different preparations have to be determined for individual patients.
The way in which the body handles drugs can show genetic variation.
Distribution of drugs around the body is likely to be different in older people because of changes in body composition, plasma protein concentration and blood flow to major organs.
The underlying pathology is thrombus formation or extension in the coronary arteries.