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Examples are magnesium salts and Picolax and polyethylene glycol. Buscopan contains hyoscine, which is an anticholinergic drug used to inhibit gastric secretion and intestinal motility during gastrointestinal imaging. Buscopan is given intravenously. Buscopan produces typical anticholinergic side effects of blurred vision, dry mouth, tachycardia and urinary retention. It should not be used in patients who have glaucoma or an enlarged prostate as it will make both of these conditions worse.
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Drugs injected subcutaneously or intramuscularly have to diffuse between loose connective tissue or muscle fibres. The rate of absorption depends on the usual parameters for passage across cell membranes but also on the blood or lymphatic supply to a particular region. Increasing the blood supply by applying heat or massage will increase the rate of absorption.
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LOCAs have lower renal toxicity than HOCAs ( kg as first choice. The frequency of contrast agent injection and dose are known risk factors for renal toxicity. Ideally, in patients at high risk of renal toxicity, there should be five days between administrations and the lowest possible dose of either non-ionic monomer or non-ionic dimer should be used. Adverse reactions include the risk of acute renal failure due to blockage of tubules because contrast agents are relatively insoluble.
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Based on anecdotal information, the following anomalies have been noted.
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For severe eczema refractory to other treatment, ciclosporin is licensed for oral use and tacrolimus is licensed for topical use. Adverse effects of cyclosporin are toxicity to bone marrow, nausea, leukopenia, blurred vision and rashes.
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Fluorouracil is a pyrimidine analogue that substitutes for uracil in the synthesis pathway for thymidylate, a necessary step in the synthesis of DNA.
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There are a number of criteria that must be met for supplementary prescribing to occur (www. gov.
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This is especially important for new drugs as adverse reactions can be missed during clinical trials. Patients as well as health care professionals can use the yellow card scheme.
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