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As the dose increases, convulsions may occur. Initially, due to central nervous system effects, the rate of respiration increases. As the drug concentration increases, depression of the medulla results in breathing becoming rapid and shallow. Larger doses depress respiration and lower the level of consciousness of the patient. Local anaesthetics can affect both autonomic nerves and the neuromuscular junction. Apart from their local anaesthetic action, local anaesthetics have anticholinergic activity.
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Buscopan is given intravenously. Buscopan produces typical anticholinergic side effects of blurred vision, dry mouth, tachycardia and urinary retention.
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Bacterial infection of the skin causes a condition known as cellulitis, which requires systemic antibiotics. As does impetigo if it is extensive, although small patches can be treated topically.
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Other techniques for local anaesthetic administration are given for the sake of completeness. EMLA (eutectic mixture of local anaesthetics; a combination of two local anaesthetics, lidocaine and prilocaine in a cream) is capable of producing skin thickness analgesia from topical administration.
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