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A drug metabolite may have a new and completely different pharmacological activity, or it may be as active as or more active than the original drug.
For the best chance of success, drugs must be used early on in a patients treatment along with irradiation or surgery when the cancer is most curable and the patient is most able to tolerate treatment.
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Since these drugs are not absorbed, side effects are confined to the intestine and include abdominal discomfort, diarrhoea or constipation. With long-term therapy, fat-soluble vitamin supplements are necessary.