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Often the condition is mediated by the immune system through inhalation of an antigen to which the individual is allergic. The antigen reacts with IgE attached to the mast cells in the lung causing the release of pharmacologically active mediators.

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Phenothiazines were developed after it was noticed that the antihistamine, promethazine had a sedative action. Chlorpromazine is the most well known and is the standard against which all other anti-psychotics are compared. It is still widely used. Anti-psychotic drugs block dopamine receptors in all four dopamine systems of the brain. Blocking of dopamine D responsible for the efficacy in therapy of schizophrenia.


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