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(Phaeochromocytoma is a benign tumour of the adrenal glands resulting in excessive secretion of adrenaline and noradrenaline. Once the secondary cause has been identified, it should be treated rather than the hypertension itself. Essential hypertension describes raised blood pressure of unknown cause. Because it is common for blood pressure to rise with age, it used to be thought that an increasing blood pressure was essential for survival, hence the name essential hypertension. It is now known that persistently raised blood pressure over a period of many years will Blood pressure varies naturally from individual to individual. Treatment of hypertension is symptomatic, aiming to maintain blood pressure below life.

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They do not take up the gram stain, but can be characterized by an acid-resistant stain. Mycobacteria are intracellular organisms and infect lung tissue mainly, but other tissues such as bones, joints and the brain can be infected. Treatment for tuberculosis is a long and difficult process, taking up to two years and requiring combinations of at least three different antibiotics. Drugs used to treat tuberculosis include isoniazid, rifampicin and pyrazinamide primarily with streptomycin and ethambutol as secondary drugs. Viruses are made up of a protein capsule, some with a lipoprotein envelope around it, containing genetic material, with maybe a few enzymes but very little else and hence they are not considered to be cells, but, rather, infectious particles. Viruses are able to bind to cell membranes, penetrate and infect cells of other organisms. Viruses are intracellular parasites; they cannot replicate themselves without using the contents of the host cell to synthesize the cellular components necessary for their reproduction.

Common cardiovascular disorders are cardiac failure, ischaemic heart disease, arrhythmias and hypertension. Although these conditions cannot be cured by drug therapy, there are many drugs available to help control them. Cardiac glycosides are useful in cardiac failure and arrhythmias because they improve myocardial contractility and slow conduction through the heart. Diuretics encourage water loss from the body and this helps reduce circulating blood volume. Consequently, blood pressure falls and this reduces the work the heart has to do.

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Adverse effects are bradycardia, heart block and possible precipitation of heart failure. Class I calcium channel blockers are contraindicated in patients who already have these conditions. Class II calcium channel blockers act primarily on smooth muscle cells and as such lead to dilation of blood vessels. This in turn reduces peripheral vascular resistance and they are used to reduce blood pressure. Examples are amlodipine and nifedipine. Nifedipine also has a use in the treatment of Raynauds disease.

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In hypertension, for example, the additive effects of multiple drug therapy is often necessary to achieve a reduction in blood pressure. Type B adverse drug reactions are much rarer than type A, but they are unpredictable and not dose-related and they are potentially more serious. Many are due to buy phentermine online with pay pal allergy, but there are other causes. Idiosyncratic reactions occur when the patient experiences an effect unrelated to the expected action of the drug. The effect is usually harmful and occurs in a very small proportion of individuals.

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An example of an anticholinesterase drug is pyridostigmine. Side effects of these drugs include excessive salivation, muscle twitching and abdominal pain, nausea and diarrhoea. Anti-inflammatory corticosteroids, for example prednisolone, can be used to suppress the antibody formation in myasthenia gravis. They should be used together with anticholinesterase drugs and once an improvement is seen the dose should be decreased. Long-term use of corticosteroids leads to serious side effects, including suppression of the pituitary-adrenal axis, immunosuppression, muscle wasting, osteoporosis and impaired wound healing.

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These antibodies attach themselves to mast cells. On subsequent exposure to the same allergen the combination of IgE and allergen causes the mast cells to release a variety of chemicals including histamine.

  • Examples of osmotic laxatives used prior to imaging are magnesium citrate and magnesium sulphate.
  • Adverse effects of class II calcium channel blockers are reflex tachycardia, headache, flushing, palpitations and ankle oedema.
  • In low oxygen tension, this type of haemoglobin crystallizes and becomes rigid.
  • Adverse effects are bradycardia, heart block and possible precipitation of heart failure.
  • If potassium ion concentration is reduced, the inhibitory effects of digoxin are increased.
  • Phase-specific drugs act at a particular point in the cycle, usually S phase or M phase.

Once inside the neuron dissociation is necessary, because it is the ionized form binds to the sodium ion channel. Local anaesthetic activity is dependent on pH, because pH determines the degree of dissociation into ions.

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The β-adrenoreceptor was the first of this type to be characterized and others seem to be similar. The structure is a single polypeptide chain spanning the membrane, folded into seven transmembrane domains and coupled to a G-protein.

The quinolones inhibit a bacterial enzyme, DNA gyrase. This enzyme is involved in the unwinding of DNA prior to replication. Inhibition of this enzyme buys phentermine online with pay pal DNA replication and bacterial cells cannot survive. Human cells contain a different form of DNA gyrase and so are unaffected by these drugs. Ciprofloxacin is a broad-spectrum antibiotic, active against both Gram-positive and Gram-negative bacteria.

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Mercaptopurine is metabolized by xanthine oxidase. It should be used with caution in combination with allopurinol because allopurinol buys phentermine online with pay pal xanthine oxidase. Both methotrexate and mercaptopurine are used to treat acute leukaemia. Fluorouracil is a pyrimidine analogue that substitutes for uracil in the synthesis pathway for thymidylate, a necessary step in the synthesis of DNA. Formation of a false nucleotide inhibits an enzyme necessary for DNA synthesis. This is similar to the mode of action of the antifungal drug, flucytosine.


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In order to avoid this relapse, the dose is often increased again and maintained. The danger then is that the patient becomes dependent on corticosteroids.

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