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The conduction pathway of electrical activity goes from the SA node to the atrioventricular node between atria and ventricles, then down the septum between the two ventricles to the apex of the heart and finally round the ventricles themselves. The conduction pathway in the heart is shown in Figure Electrical activity in the heart can be picked up by electrodes placed on the skin and recorded as the familiar electrocardiogram. The ECG is a record of the sum of all action potentials in the heart as it contracts. Action potentials are generated by depolarization followed by repolarization of the cardiac muscle cell membrane. Depolarization is initiated by an influx of sodium ions into the cardiac muscle cells, followed by an influx of calcium ions. Repolarization is brought about by efflux of potassium ions.

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See Figure (In some definitions, parenteral is synonymous with injection (for example in the Medicines Act), but here the term is used to describe all routes of administration that are not enteral.

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They are known as contrast agents or contrast media and are usually based on iodine, barium or gadolinium containing compounds. These substances are injected, swallowed or introduced rectally.

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