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Normally potassium ions compete with cardiac glycosides for their site of action, which is the NaK ATPase pump in the cardiac muscle cell membrane. If potassium ion concentration is reduced, the inhibitory effects of digoxin are increased. Diuretics may also increase plasma lipid levels and cause glucose intolerance and insulin resistance, so they have to be used with caution in individuals with hyperlipidaemia andor diabetes. In addition, most diuretics produce an increase in plasma uric acid levels, which may lead to gout. ACE inhibitors are used to treat cardiac failure and hypertension.
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The human brain is a complex organ made up of over as many glial cells. It is organized into systems, which sense, process and store, perceive and act on information received from outside and inside the body.
Sodium ion channels can be in three different states open, closed or inactive.
Their formation may be due to abnormal metabolism of a precursor protein. Neurofibrillary tangles are found in neurons and may be collections of abnormal microtubule proteins, which form as a result of cell destruction.
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