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Other techniques for local anaesthetic administration are given for the sake of completeness. EMLA (eutectic mixture of local anaesthetics; a combination of two local anaesthetics, lidocaine and prilocaine in a cream) is capable of producing skin thickness analgesia from topical administration. The cream is applied for a period of occlusive dressing.

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This receptor is found at the neuromuscular junction. It is a protein consisting of five subunits, two α and one each of β, γ and δ, which are arranged in the membrane around the channel. Acetylcholine binds to the α subunits. Thus, each receptor has two binding sites and both must be occupied for the receptor to be activated.

Both drugs have similar side effects of nausea, vomiting, dizziness, blurring of vision and headache, although those of quinine can be more severe. Halofantrine is another antimalarial drug that is being used more now that resistance to chloroquine and quinine has developed. Its mode of action is not known. Side effects are gastrointestinal disturbances and headache.

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The third case study is a patient who any health care professional might see for different reasons. Mrs Charles is a middle-aged patient who has an ingrowing toenail and requires a TNA. She is aware that she suffers from a disorder with a long name, which makes her muscles weak. Mrs Charles currently requires a wheelchair in which she is pushed around by her carer. Mrs Charless drug therapy is pyridostigmine bromide prednisolone Discuss the treatment of this patient using the questions below as a guide. They are intended to stimulate discussion not limit debate.

Authored by Mr. Sadril Mohammad, PA-C

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You should be able to answer the following review questions from the topics covered in the preceding chapter. and how might you predict if a patient is likely to have an allergic reaction to a particular drug.

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