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New nucleotides pair C cytosine G guanine T thymine A adenine base sugar base phosphate Figure with the existing bases of each strand: adenine nucleotides pair with thymine; guanine nucleotides pair with cytosine. This process is catalysed by an enzyme called DNA polymerase.
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Their use depends on their ability to inhibit the activity and proliferation of lymphocytes and other leukocytes and because of this they are very toxic to the bone marrow.
For example, amphetamine is now spelt amfetamine and lignocaine is now lidocaine. Where this has happened, both names are listed in the BNF.
As the free drug is transported, more of the drug dissociates from the protein binding site and can be eliminated. Substances transported by the same transport system compete with each other and the more slowly a drug is transported the more effective it is at inhibiting the transport of another.
Some imidazoles enhance the anticoagulant properties of warfarin. Adverse effects with topical preparations are irritation and itching of the skin.
Age-dependent changes in the liver have the most impact on drug metabolism.