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Examples of SSRIs include fluoxetine and sertraline. The principal side effects include nausea, diarrhoea, insomnia and agitation. There are other drugs not classified as SSRIs but which work in similar ways.
Injection of drugs. and active transport of drug molecules across cell membranes. the gastrointestinal tract, its distribution around the body and its excretion by the kidneys.
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The cause of multiple sclerosis is unknown and there is no cure. Interferon β has been used for patients with relapsing intermittent multiple sclerosis who can walk unaided. However, this drug is no longer recommended by NICE for this purpose. Short courses of corticosteroids are used during exacerbations and seem to reduce the effect of a relapse. Spasticity is a common symptom in multiple sclerosis.
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Lithium is similar to sodium in that it forms positive ions and can pass through sodium ion channels in neuronal cell membranes. It tends to accumulate inside neurons and may interfere with nerve action potentials or the activation of second messenger systems within the neuron. In addition, lithium may inhibit the release of monoamines from nerve endings and increase their uptake. However, the exact mode of action of lithium in affective disorders is unknown. Lithium has a narrow therapeutic ratio and blood concentration must be carefully monitored to avoid toxicity.
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Inhibitors of TNF-α Inhibitors of TNF-α are used in highly reactive rheumatoid arthritis, severe ankylosing spondylitis and active progressive psoriatic arthritis that have not responded to at least two DMARDs.
Allergy to local anaesthetics is possible, although this is not common. It is most likely in people who have regular contact with local anaesthetics such as dentists and anaesthetists.
They are bactericidal and most effective on rapidly dividing bacteria.
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New drugs come on the market, and others are withdrawn or reclassified. Reliable sources of information are the British National Formulary, the British Pharmacopoeia and summaries of product characteristics supplied by medicines manufacturers.