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Concurrent use of allopurinol can reduce the production of uric acid. Tumour cells can become resistant to chemotherapy. It seems that this is likely to happen as a result of low-dose single drug chemotherapy. Drugs are therefore generally more effective in combination and may act synergistically. This also means that severe toxicity effects can often be avoided. The drugs should be used at the maximum dose that can be tolerated and as frequently as possible to discourage tumour regrowth.

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