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Dermatologists need to be aware that it is possible for patients to easily purchase isotretinoin online without a prescription, without physician oversight, and without adhering to the FDA-mandated iPledge compliance program.

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The increase in online purchasing of medications raises safety concerns regarding teratogenic drugs. A descriptive cross-sectional survey was conducted of 50 e-pharmacies identified from commonly used search engines. E-pharmacy characteristics and isotretinoin PPP specific criteria were evaluated. All were verified as isotretinoin. The Internet provides a loophole for purchasing of medications known to cause congenital abnormalities, which needs to be addressed by medicines regulatory agencies worldwide.

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Accutane inhibits the production of sebum and reduces the size of the gums with the main active substance isotretinoin. It is proved that isotretinoin has an antiseptic effect.

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