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Monotherapy with a selective serotonin reuptake inhibitor SSRI is the most common initial treatment for major depressive disorder MDD, but this monotherapy leads to remission in fewer than a third of patients. The combination of the SSRI escitalopram and bupropion-SR is commonly used for treating patients with MDD who have had an inadequate response to antidepressant monotherapy.

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Common side effects of bupropion include a dry mouth, difficulty sleeping, agitation, and headaches.

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Bupropion is a smoking cessation aid that can help reduce nicotine cravings and withdrawal symptoms. For smoking cessation, bupropion is prescribed for a week course.

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A randomized six-way crossover study was conducted in healthy volunteers. Cite this article Connarn, J.
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