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Randomized, repeated-measures study designs were employed.

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Nucynta ER tapentadol is a member of the narcotic analgesics drug class and is commonly used for Diabetic Peripheral Neuropathy and Pain.

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Our results indicate that tapentadol ER is rarely sold illicitly in the United States.

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The pain intensity difference PID was to be calculated as baseline pain minus current pain at each assessment time point. Drug: Oxycodone IR 5, 10, or 15 mg every 4 to 6 hours for up to 10 days as needed for pain.

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Tapentadol Nucynta is a centrally-acting opioid analgesic approved for the relief of moderate to severe pain in adults. It has two mechanisms of action: in addition to acting at the mu opioid receptor, tapentadol blocks norepinephrine uptake, although the clinical relevance of this additional action is not known.
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