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Some drugs physically block channels. For example, local anaesthetics block sodium ion channels in neuronal cell membranes ( or facilitating the opening of the channel, for example calcium channel blockers. Carrier proteins are involved in the transport of many molecules across cell membranes. Neurotransmitter carrier mechanisms are of particular interest since many drugs have been developed that interfere with this process. Carrier proteins can be inhibited by drugs or persuaded to pick up false transmitters. For example, selective serotonin reuptake inhibitors inhibit membrane carriers for serotonin, and methyldopa is taken up into neurons by the carrier for dopa and subsequently converted to the false transmitter methylnoradrenaline.
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When the tourniquet is removed, there is the risk of systemic side effects due to large amounts of anaesthetic reaching the general circulation.
29.02.2020
Arnold
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Dorothea
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29.08.2020
Johannes
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Symptoms recede when the stress or exertion ceases.
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