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Some patients have developed myopathy andor myalgia, which have to be monitored. Statins can interact with many other drugs; some of which can result in increased risk of myopathy. Ezitimibe inhibits absorption of cholesterol from the intestine, probably by interfering with a cholesterol transport system. It is used as an adjunct to therapy with statins in patients with severe hyperlipidaemia, or alone if statins are not tolerated. Adverse reactions to ezitimibe are gastrointestinal disturbances, headache, fatigue and myalgia.

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Resistant hypertension can be treated with add-on drugs α Arrhythmias can also be treated with membrane stabilizers and amiodarone. Disorders of coagulation, anaemia and hyperlipidaemia are relatively common, particularly in older patients.

  • Mood disorders are associated with changes in regional brain function, which is different to those seen in non-depressed patients who feel sad.
  • Severe and potentially fatal inflammation can occur if the gastrointestinal tract is perforated and the barium contrast agent escapes into the peritoneal cavity.
  • Conversely, for a local effect, addition of a vasoconstrictor to the injection decreases the rate of removal of the drug from the site of injection.
  • Centrally acting analgesics are also known as narcotics or opioids.
  • Examples of PGDs relevant to podiatric surgery are shown in Appendix C.
  • Indometacin is a much more potent anti-inflammatory drug but poorer analgesic than aspirin.

Infection with parasitic worms in the United Kingdom is usually confined to round worms or thread worms. In tropical and subtropical parts of the world, infection with parasitic worms is common and widespread.

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They also have a slight diuretic effect. Xanthines are of principle use in the immediate phase reaction of asthma but also have some effect on the late phase reaction.

However, on examining the definition of an independent prescriber, it is clear that they meet the requirements. The interesting aspect of this practice is that a major growth area of radiographer role advancement currently is the reporting of accident centre images by radiographers, which is a precursor to radiographer-led discharge and the associated supply and administration of medicines. Anticipating that radiographers will gain independent prescribing responsibilities at some stage, then the following is suggested. PGDs will continue to be used where large groups of patients undergo imaging procedures that routinely require medicinal administration in a set format, as indicated earlier. This method of working minimizes the need to train large groups of staff to a high level while still maintaining sensitivity to individual patient needs.

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Anthelmintics have the following modes of action: cause paralysis of the worm; damage the cuticle of the worm leading to partial digestion or attack by the immune system; interfere with the metabolism of the worm. Many anthelmintics are available in the United Kingdom only on a named-patient basis. These are unlicensed medicines that have not been given a Marketing Authorization by the Medicines and Healthcare Products Regulatory Agency and can only be obtained from the pharmaceutical company or manufacturer. This is a major group of anthelmintics. Mebendazole is a broad-spectrum anthelmintic effective against threadworms, hookworms and round worms.


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