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Before that, salicylic acid had been used medicinally since antiquity. Medicines made from willow and other salicylate -rich plants appear in clay tablets from ancient Sumer as well as the Ebers Papyrus from ancient Egypt. In, scientists at the drug and dye firm Bayer began investigating acetylsalicylic acid as a less-irritating replacement for standard common salicylate medicines, and identified a new way to synthesize it. Aspirin's popularity grew over the first half of the twentieth century leading to fierce competition with the proliferation of aspirin brands and products. In the s and s, John Vane and others discovered the basic mechanism of aspirin's effects, : — while clinical trials and other studies from the s to the s established aspirin's efficacy as an anti-clotting agent that reduces the risk of clotting diseases. Medicines derived from willow trees and other salicylate-rich plants have been part of pharmacopoeias at least dating back to ancient Sumer.
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Examples of drugs that are GSL items, subject to quantity and retention of original packaging, are aspirin and paracetamol, antacids and some topical anti-fungal creams. Pharmacy medicines may only be supplied to the public from a pharmacy or other registered premises by or under supervision of pharmacist.
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