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Donepezil works by blocking the action of acetylcholinesterase, an enzyme that breaks down acetylcholine, a brain chemical believed to be important for memory and thinking. The effect of the drug is to cause acetylcholine levels to remain high for longer periods of time. This is believed to help in the proper function of the human nervous system, including the brain. Aricept is manufactured and marketed by Eisai Co. On October 13, Aricept was approved for severe AD at a dose of 10mg once a day.

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Patients must have been taking 10 mg IR or a bioequivalent generic for at least 3 months prior to Screening. The study will consist of 24 weeks of daily administration of study medication, with clinic visits at Screening, Baseline, 3 weeks safety only, 6 weeks, 12 weeks, 18 weeks and 24 weeks or early termination. Patients will receive either 10 mg donepezil IR in combination with the placebo corresponding to 23 mg donepezil SR, or 23 mg donepezil SR in combination with the placebo corresponding to 10 mg donepezil IR. A total of approximately patients will be enrolled to obtain complete data from approximately completed patients Revised per Amendment During the Baseline visit, patients will be randomized in a ratio 23 mg donepezil SR to 10 mg donepezil IR. Patients who complete the study may be eligible to undergo evaluation for enrollment into the open-label extension study, EG Patients will receive study medication orally, once daily, for 24 weeks according to a double-dummy design.

Common side effects include nausea, trouble sleeping, aggression, diarrhea, feeling tired, and muscle cramps. Donepezil was approved for medical use in the United States in There is no evidence that donepezil or other similar agents alters the course or progression of Alzheimer's disease. Food and Drug Administration aricept 23 mg generic approved donepezil for treatment of mild, moderate and severe dementia in Alzheimer's disease. In clinical trials the most common adverse events leading to discontinuation were nausea, diarrhea, and vomiting. Side effects are mild and transient in most patients, lasting up to three weeks and usually improved even with continued use.

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Tabs: Swallow whole with water. Adverse Reactions: Nausea, diarrhea, vomiting, insomnia, muscle cramps, fatigue, anorexia, weight loss esp.

Take this medicine exactly as directed by your doctor in order to improve your condition as much as possible. Do not take more of it or less of it, and do not take it more or less often than your doctor ordered. Donepezil should be taken at bedtime unless otherwise directed by your doctor. It may be taken with or without food, on a full or empty stomach. The dose of this medicine will be different for different patients.

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It improves mental functions including attention, memory, and the ability to interact and speak with others by preventing the naturally occurring neurotransmitters in the brain from breaking aricept 23 mg generic. Currently, donepezil is the world's best-selling Alzheimer's drug. In, Aricept was approved to treat severe dementia in people with Alzheimer's. Donepezil has also been tested in patients with schizophrenia, attention deficit disorder, and mild cognitive impairment. Donepezil must be taken as prescribed, even if you feel good, to be effective.

Abdominal pain, agitation, periactin price, cholecystitis, convulsions, heart block all types, hemolytic anemia, hepatitis, hyponatremia, neuroleptic malignant syndrome, pancreatitis, rash, rhabdomyolysis, QTc prolongation, Stevens Johnson syndrome toxic epidermal necrolysis and torsade de pointes. Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Abdominal pain, agitation, aggression, cholecystitis, convulsions, heart block all types, hemolytic anemia, hepatitis, hyponatremia, neuroleptic malignant syndrome, pancreatitis, rash, rhabdomyolysis, QTc prolongation, Stevens Johnson syndrome toxic epidermal necrolysis and torsade de pointes. Cholinesterase inhibitors are likely to exaggerate succinylcholine-type muscle relaxation during anesthesia. Cholinesterase inhibitors may have vagotonic effects on the sinoatrial and atrioventricular nodes manifesting as bradycardia or heart block. Cholinesterase inhibitors should be prescribed with care with history of asthma or aricept 23 mg generic pulmonary disease. Use with caution in patients with history of seizure disorders, urinary tract obstruction, peptic ulcer disease, cardiac conduction abnormalities, or respiratory disease including COPD or asthma. May be associated with QT prolongation and torsades de pointes; use caution in patients at risk of cardiac repolarization.

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