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In the past 5—10 years there has been a growing trend for substituting conventional 5-fluorouracil with the oral prodrug of 5-fluorouracil, capecitabine, in chemotherapy regimens. This regimen change is based on evidence of the efficacy equivalence of these two drugs and the lack of an increase in overall toxic effects when capecitabine is used. |
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German researchers conducted a phase I, dose-escalation study to determine the maximum tolerated dose of oral capecitabine given concurrently with standard pelvic radiotherapy in patients with rectal cancer treated in the adjuvant, neoadjuvant, or palliative setting. Radiotherapy was given to a total dose of |
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