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Drug development involves investigation of drug action in order to determine suitable and effective dosage regimes, to allow likely adverse effects to be determined and to ensure safety in use as far as possible.

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Monocytes and macrophages are infected but not necessarily destroyed, so they serve as a reservoir of infection. In addition, macrophages present virus to T lymphocytes, so there is direct spread from cell to cell without the virus entering plasma where it would be attacked by antibodies.

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