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This interferes with the normal base pairing of guanine with cytosine and allows cross-linking of guanine with other guanine molecules in the same strand and opposite strand of DNA. This denatures the DNA and as a result transcription of DNA for protein synthesis and replication of DNA for cell division are disrupted. The end result is cell death by apoptosis. Although alkylating agents can act on cells at any stage of the cell cycle, they are most effective in the S phase of buy phentermine k 25 cell cycle and are therefore most cytotoxic to rapidly dividing cells. Of the drugs in this group, cyclophosphamide is commonly used to treat chronic lymphocytic leukaemia, lymphoma and ovarian and testicular cancers. Cyclophosphamide produces severe nausea and is often used with a ondansetron.
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Thus, phenytoin may show increased or decreased activity. Other drugs, for example phenobarbital, compete for the same liver enzymes.
15.10.2019
Mechthild
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Adverse effects include postural hypotension, bradycardia and fluid retention.
12.08.2017
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What can you tell her about this and is there anything else you could advise the patient and her family about.
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